|
KMID : 1059520080520060622
|
|
Journal of the Korean Chemical Society
2008 Volume.52 No. 6 p.622 ~ p.629
|
|
|
Development and Validation of Simultaneous UV Spectrophotometric Method for the Determination of Levofloxacin and Ambroxol in Tablets
|
|
Patil Tabassum
Pore Yogesh
|
|
|
Abstract
|
|
|
|
An accurate, specific and precise UV spectrophotometric method was developed for the simultaneous determination of levofloxacin (LFX) and ambroxol (ABX) in pharmaceutical dosage forms. The method involves formation of Q-absorbance equation at 219 (isoabsorptive point) and at 287 nm, using distilled water as a solvent. The linearity for both levofloxacin and ambroxol was in the range of 2-20 μg/ml and 5-50 μg/ml respectively. The % recovery was found to be 100-101% and 99-102% for levofloxacin and ambroxol respectively indicating proposed method is accurate and precise for simultaneous estimation of levofloxacin and ambroxol in tablets.
|
|
|
KEYWORD
|
|
|
Levofloxacin Hemihydrate, Ambroxol Hydrochloride, UV Spectrophometry, Q analysis, Dosage Form
|
|
|
FullTexts / Linksout information
|
|
|
|
|
|
Listed journal information
|
|
|